An unlocking method for an electronic device with a touch screen, comprises displaying a plurality of unlocking buttons and indicating the touching sequence for touching the buttons on the touch screen when the touch screen is in a locked state in which the user interface is locked; detecting contact with the touch screen and determining whether the plurality of unlocking buttons are touched according to the indicated touching sequence; switching the user interface into an unlocked state if the plurality of buttons is touched according to the indicated touching sequence; and keeping the user interface in the locked state if the plurality of buttons are not touched according to the indicated touching sequence. The method is simple and convenient and can prevent unlocking through incorrect operation.