The invention discloses a method and device for controlling uplink signal power. The method includes that a corresponding relation of closed loop power control commands and power revising value for a distributed antenna system and a CoMP system is built; an evolved node B (eNB) judges whether the corresponding relation is used for controlling user equipment (UE) to conduct uplink transmission power adjustment according to UE signals received by all receiving nodes; and on yes judgment, the eNB informs the UE to adjust the uplink transmission power according to the corresponding relation. By means of the technical scheme, a closed loop power adjusting capacity effect of long term evolution (LTE)/LET-A system is effectively improved, and a problem in the prior art that when the UE is arranged in the distributed antenna system or the CoMP system, the base station can not adjust UE uplink signal power reasonably is solved.