A method and device for multi-access point calibration are disclosed. The method includes: a base station estimating a value closest to a true parameter deviation in a value interval of an uplink and downlink channel parameter deviation between access points, wherein the parameter deviation includes a phase difference and an amplitude difference; and the base station performing phase and/or amplitude calibration on service data transmitted jointly by the access points according to the value. With the method and device provided in the present invention, a cell calculates a parameter difference between different access points, and then calibrates multiple access points according to the parameter difference, so as to solve a problem that the phase difference and amplitude difference exist between the data transmitted jointly between the multiple access points, and thus it can be guaranteed that good coherent transmission is performed between the access points, thereby improving the system performance.