The invention relates to a manufacturing method of a negative pressure drying silk-screen printing plate. According to the method, uniform pressure is formed on a to-be-dried light-sensitive substance on the screen printing plate in a negative pressure state, and the to-be-dried light-sensitive substance surface which is approximate to a plane is formed after rapid drying under the action of the pressure, so that a good screen printing plate printing surface is obtained. The silk-screen printing plate prepared with the method has neat and smooth pattern edges, problems of sawteeth, dogteeth and the like are solved, and a printed pattern is clearer and more precise.