The invention discloses an unattended substation remote control inspection device with a guide wheel. The unattended substation remote control inspection device comprises an on-site image pickup device and a monitoring room monitor device, wherein a track is arranged on site for the on-site image pickup device, an electronic eye moving along the track and enabling two cameras to rotate all around is arranged on the track, and the monitoring room monitor device is connected with the on-site image pickup device through a network. The unattended substation remote control inspection device achieves functions of daily video inspection of equipment in an unattended substation equipment area and appearance multi-angle checking during equipment failure, ensures normal operation of a power device and guarantees normal power supply.