The invention discloses a full-automatic unmanned vacuum air-conditioning sealing packing machine with a dust extraction function. The full-automatic unmanned vacuum air-conditioning sealing packing machine comprises a main machine frame, a bag opening device, a bag clamping device, a sealing device, an air exhausting device, an air extractor, a dust extraction device and a conveying device. The bag opening device, the bag clamping device, the sealing device, the air exhausting device, the air extractor, the dust extraction device and the conveying device are installed on the main machine frame. According to the full-automatic unmanned vacuum air-conditioning sealing packing machine with the dust extraction function, automatic operation is achieved through cooperation of various functions such as automatic bag opening, bag clamping, air exhausting, air extracting, sealing and conveying; the using efficiency of the machine is improved; used labor cost are greatly reduced; social resources are saved.