The invention provides a composition for treating patients of tuberculosis. The composition comprises a Notch signal pathway inhibitor, wherein the Notch signal pathway inhibitor is any one or more of all substances capable of inhibiting a notch signal pathway; and preferably, the Notch signal pathway inhibitor is a chemical blocker including the notch signal pathway, and the chemical blocker is capable of inhibiting functional siRNA and shRNA segments of a notch gene and is capable of inhibiting any one or more of functional monoclonal antibody and polypeptide of notch protein. The invention also provides application of the composition. Functions of the composition for treating patients of tuberculosis are available on the basis of experimental verification; and in the process of treating patients of tuberculosis, the composition is low in side effect, convenient and flexible in treatment course and is capable of achieving a purpose of healing.