The invention relates to a recombinant insulin secretion promoter fusion protein. A polypeptide zone of the recombinant insulin secretion promoter fusion protein comprises a human serum albumin and an insulin secretion promoter. The insulin secretion promoter in a form of one or more monomers is connected to the human serum albumin in series by a connecting peptide. An amino terminal and/or a carboxyl terminal of the insulin secretion promoter are connected to a carboxyl terminal and/or an amino terminal of the human serum albumin by a connecting peptide. The number of the amino acid sequences for coding the connecting peptides is equal to the number of the amino acid sequences for coding the insulin secretion promoter. The recombinant insulin secretion promoter fusion protein has the advantages of good drug effects, long half life, simpleness, high efficiency, safety and good application prospect.