The embodiment of the invention discloses a virtual reality (VR) equipment-based device for centering a screen of a mobile terminal and the VR equipment, and aims to achieve the effect of centering the screen of the mobile terminal relative to a mobile terminal accommodating groove by adjusting the relative position of the mobile terminal through a longitudinal adjusting mechanism and a transverse adjusting mechanism. The device for centering the screen of the mobile terminal based on the VR equipment comprises the transverse adjusting mechanism and the longitudinal adjusting mechanism, wherein the transverse adjusting mechanism comprises a first surface which is arranged on a bottom plate of the mobile terminal accommodating groove of the VR equipment; the longitudinal adjusting mechanism comprises a cover provided with two adjusting holes in the longitudinal direction, namely, a left adjusting hole (1) and a right adjusting hole (2); the transverse adjusting mechanism is used for centering the screen of the mobile terminal relative to the transverse direction of the mobile terminal accommodating groove; the longitudinal adjusting mechanism is used for centering the screen of the mobile terminal relative to the longitudinal direction of the mobile terminal accommodating groove.