The present invention discloses an ultrahigh pressure sterilization effect enhancing method. The method uses an acidic electrolyzed water as an ultrahigh pressure liquid medium and conducts an ultrahigh pressure sterilization for aquatic products. The pH value range of the acidic electrolyzed water is 2.28-2.39, the range of oxidation-reduction potential is 1077-1168 mV, and the range of effective chlorine content is 36-73 mg/L. The method innovatively uses the acidic electrolyzed water as a new pressure transmission medium for ultrahigh pressure technology, builds a whole new sterilization technology, serves the food industry, reduces the disease risks of pathogens and provides a strong technical support for protecting public hygiene.