The invention discloses a multi-screen response type webpage layout adjustment method. The multi-screen response type webpage layout adjustment method specifically comprises a multi-screen self-adapting method and an individual webpage layout adjustment method. The multi-screen self-adapting method comprises the steps of ensuring webpage content to match with a screen by automatically adjusting the width of the webpage content based on a screen size; and enabling the size of the content of each part in the webpage to change adaptively along with the change of the webpage width. The individual webpage layout adjustment method comprises the steps of realizing grid arrangement as a webpage layout structure regards a 12-grid system of Bootstrap as a basis; finishing function component layout in a webpage through drag and drop operation of a mouse as dragging and placement provided by jQuery UI is adopted; adaptively changing the width of a webpage content display region along with the size of a display screen of a mobile device through a change rule of the response type webpage content width, and providing a change rule of the response webpage content width.