A system and methods for slow medium access control entity (MAC-e) for autonomous transmission during High Speed Uplink Packet Access (HSUPA), and for service specific transmission time control in HUSPA, wherein a control parameter that is independent from the air interface transmission time interval (TTI), hybrid automatic repeat request (HARQ) processes or enhanced dedicated transport channel (E-DCH) scheduling is used. This control defines the minimum time interval between subsequent new transmissions. The control has no impact on retransmissions, which are performed normally.