The invention belongs to the biological medicine field, and in particular, relates to a polypeptide for inhibition of blood vessel neogenesis or growth, a coding sequence, a vector containing the coding sequence, host cells, pharmaceutical compositions and a pharmaceutical use of the polypeptide. The polypeptide has the advantages of small molecular weight, good water solubility, high safety and good stability, and can be prepared by a solid phase synthesis method; and the purity is high, the yield is high and the cost is low.