The invention discloses a preparation method of a compound saussurea involucrate burn and scald ointment. The preparation method comprises the following steps that 120-140 g of saussurea involucrata flowers, 90-110 g of radix arnebiae seu lithospermi, 0.4-0.5 g of stigma croci, 1.0-1.6 g of bear gall powder, 0.2-0.4 g of musk and 35-40 g of borneol are taken; stigma croci, the bear gall powder, musk and borneol are crushed into fine powder and then screened; saussurea involucrata flowers are decocted twice by adding water, filtering is conducted to obtain saussurea involucrata flower filtrate, the saussurea involucrata flower filtrate is concentrated into thick paste, the thick paste is dried to obtain saussurea involucrata flower dry extract powder, and the saussurea involucrata flower dry extract powder and the fine powder are mixed to be uniform and then screened; 1,000 g of sesame oil is taken, radix arnebiae seu lithospermi is immersed into the sesame oil, and impregnating under heat preservation is conducted to obtain radix arnebiae seu lithospermi oil; bee wax is taken according to the proportion that 1.2-1.5 g of the bee wax is taken for every 10 g of the radix arnebiae seu lithospermi oil, the bee wax is heated to be melt and then uniformly mixed with the radix arnebiae seu lithospermi oil, the fine powder is added into the materials, uniform stirring and filling are conducted, and then the compound saussurea involucrate burn and scald ointment is obtained. The preparation method is short in cycle and simple in process and can be applied to industrialized production.