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Invention Grant
CN105950563B 杂交瘤细胞株7E3及其分泌的抗口蹄疫A型病毒的单克隆抗体与应用 有权 转让

杂交瘤细胞株7E3及其分泌的抗口蹄疫A型病毒的单克隆抗体与应用
Abstract:
本发明公开了一种能持续、稳定分泌抗口蹄疫A型(Re‑A/WH/09)病毒单克隆抗体的杂交瘤细胞株7E3，并由该细胞株分泌得到单克隆抗体7E3anti及其应用。本发明的单克隆抗体能够特异性地识别口蹄疫A型(Re‑A/WH/09)病毒，可用于双抗体夹心法检测口蹄疫A型(Re‑A/WH/09)病毒抗原浓度；或者用于竞争法检测口蹄疫A型病毒抗体水平，灵敏度高、特异性好，可用于疫苗生产、产品质检中对口蹄疫A型(Re‑A/WH/09)病毒抗原的检测或口蹄疫A型(Re‑A/WH/09)病毒疫苗免疫后抗体水平的评价。
Abstract(English):

The invention discloses a hybridoma cell strain 7E3 capable of constantly and stably secreting a monoclonal antibody resistant to the FMD type A virus (Re-A/WH/09), a monoclonal antibody 7E3anti secreted by the cell strain, and application. The monoclonal antibody can specifically recognize the FMD type A virus (Re-A/WH/09) and can be used for detecting the concentration of the FMD type A virus (Re-A/WH/09) antigen with the double antibody sandwich method, or for detecting the level of the FMD type A virus (Re-A/WH/09) antibody with the competition method. The monoclonal antibody is high in sensitivity and specificity, and can be used for detecting the FMD type A virus (Re-A/WH/09) antigen or evaluating the level of the FMD type A virus (Re-A/WH/09) antibody after vaccine immunity in vaccine production and product quality inspection.

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