The invention discloses a natural gas gathering pipeline blockage remover. The natural gas gathering pipeline blockage remover is prepared from 70%-80% of mixed acid, 2%-5% of additive and the balance water, and the content sum of the components is 100%. The problem that the treatment effect of an existing blockage remover sold on the market on carbonate scale is poor is solved. The invention further discloses a preparation method of the blockage remover. The method specifically comprises the steps that 1, the raw materials are weighed in proportion; 2, nitric acid, sulfuric acid and water are firstly added in proportion to prepare the mixed acid, and then stirring is carried out; 3, the needed water is added in proportion, and full stirring is carried out; 4, then the additive is added, and stirring is carried out. The invention further discloses a pipeline blockage removal method utilizing the blockage remover.