The invention provides a chest temperature abnormal zone positioning method and device, belonging to the human body temperature measurement technical field. The method comprises: identifying a characteristic part on a breast; predicting a temperatures interest region according to multipoint temperature sampling values on the breast collected by a temperature collection device; and based on the direction of the characteristic part, indicating a user to relocate the temperature collection device to the temperatures interest region. The technical scheme can realize the comprehensive monitoring of chest temperatures and the monitoring of interest points with least temperature sensors, and reduce the complexity and cost of temperature sensing equipment, as well as the complexity of a temperature signal post-treatment algorithm.