The invention discloses a method for preparing freeze-dried dendrobium officinale wine. The freeze-dried dendrobium officinale wine is prepared from 30-60% vol baijiu and ultrasonic extracting solution. The ultrasonic extracting solution is prepared from 20-40 parts of freeze-dried dendrobium officinale, 10-30 parts of fructus lycii, 10-30 parts of ginseng and 10-30 parts of cordyceps militaris through ultrasonic extraction. During preparation of the freeze-dried dendrobium officinale wine, 1000 parts by weight of baijiu and 30-180 parts by weight of ultrasonic extracting solution are evenly mixed, the mixture stands at 2-10 DEG C for 24-48 h, supernate is filtered with a 2000-mesh filter material, filling is conducted, and curing is conducted for five days so that the finished wine can be obtained. In this way, effective constituents in dendrobium officinale can be reserved, tissue structure is intact without deformation, the number of extracted effective constituents is large, extraction efficiency is high, and extraction time is short; the prepared finished wine can improve the immunity of people, promote blood circulation, resist fatigue and tonify liver and kidney.