The invention relates to the technical field of display, in particular to a color film substrate, a driving method thereof, a display panel and a display device. The problem that an existing traditional black matrix cannot effectively improve light leakage of a shading region is solved. The color film substrate comprises a first controllable shading portion and a second controllable shading portion which are located on an orthographic projection on the substrate and on the two sides of a black matrix strip extending in the first direction and/or the second direction. On the premise that the width of the existing black matrix strip is not changed, the controllable shading portions of the shading region can be controlled to be in a shading shape, so that the purpose of light leakage caused when the shading region for shading signal lines is not uniform in orientation is achieved; meanwhile, the controllable shading portions of the non-shading region are kept to be transparent, so that the certain opening rate is ensured. Accordingly, the problem of light leakage of the shading region of the signal lines is effectively solved, and the display quality is improved.