The invention discloses a traditional Chinese medicine preparation for treating heart failure with preserved ejection fraction. The traditional Chinese medicine preparation is prepared from the following ten traditional Chinese medicines according to a certain proportion: radix ophiopogonis, fructus corni, rhizoma polygonati, rhizoma coptidis, snakegourd peel, earthworm, turtle shell, radix salviae miltiorrhizae, rhizoma pinelliae, fructus aurantii and the like. The traditional Chinese medicine preparation is mainly used for treating the heart failure with preserved ejection fraction, or heart failure and other diseases having clinical syndromes of yin deficiency with blood stasis with or without phlegm and fluid retention, and has the effects of nourishing yin, benefiting qi, activating blood, expelling phlegm and promoting urination. The traditional Chinese medicine preparation is precise and appropriate in medicine use, rigorous in compatibility of medicines and remarkable in curative effect; compared with simple western medicine intervention, the traditional Chinese medicine preparation has the advantages of further improving the clinical symptoms and psychological state of a patient who has the heart failure with preserved ejection fraction or the heart failure having clinical syndromes of yin deficiency with blood stasis with or without phlegm and fluid retention, improving quality of life, increasing exercise tolerance, reducing rehospitalization rate, and the like; furthermore, the traditional Chinese medicine preparation is safe to take and free from obvious toxic or side effects, and can be popularized and applied clinically.