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Invention Grant
CN106148257B 改造的克雷伯氏肺炎杆菌及其生产葡萄糖酸的应用 有权

改造的克雷伯氏肺炎杆菌及其生产葡萄糖酸的应用
Abstract:
本发明公开了一种改造的克雷伯氏肺炎杆菌及其生产葡萄糖酸的应用。该改造的克雷伯氏肺炎杆菌为葡萄糖酸脱氢酶失活的克雷伯氏肺炎杆菌。通过将克雷伯氏肺炎杆菌中葡萄糖酸脱氢酶的编码基因进行失活来获得所述改造的克雷伯氏肺炎杆菌。利用所述改造的克雷伯氏肺炎杆菌生产葡萄糖酸，具有较高的底物转化率，较高的生产强度和较高的产物终浓度。
Abstract(English):

The invention discloses improved Klebsiella pneumoniae and application thereof in producing gluconic acid. The improved Klebsiella pneumoniae is Klebsiella pneumoniae with gluconate dehydrogenase inactivated. The improved Klebsiella pneumoniae is obtained by inactivating the encoding gene of the gluconate dehydrogenase in the Klebsiella pneumoniae. When the improved Klebsiella pneumoniae is used for producing gluconic acid, a high substrate conversion rate, high production strength and a high product final concentration are achieved.

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