The invention discloses a diagnosis and treatment target-IGSF6 gene for the multiple myeloma. By detecting the content of the IGSF6 gene and expression products of the IGSF6 gene in myeloid tissue of a testee, whether the testee suffers from the multiple myeloma or not can be judged or whether the testee bears a risk of suffering from the multiple myeloma or not can be diagnosed. In addition, by studying the proliferation, migration and invasion indexes of in-vitro cultured cells of the multiple myeloma, it is proved that the IGSF6 gene serves as a medicine target for treating the multiple myeloma.