In a wireless network environment, in which exist a plurality of femtocell networks and a macrocell network, an interference management precoding technology aiming at a plurality of users in a heterogeneous network is provided. A macrocell base station and a plurality of femtocell base stations are disposed in a cell in a covered manner. The interferences of the macrocell network on the femtocell networks are defined as cross-layer interferences, and the interferences among the femtocell networks are defined as same-layer interferences. Femtocell users and macrocell users are precoded. By adopting the precoding of the macrocell users, the cross-layer interferences are minimized, and then the cross-layer interferences can be compared with background noises. The iteration of the precoding of the femtocell users and the postposition coding of the femtocell base stations is carried out, and is output by adopting a minimum mean square error criterion, and finally, the interferences on the femtocell base stations are greatly reduced, and the service quality of the femtocell users is guaranteed.