The invention provides a thin film sensor array calibration device and calibration method based on sound pressure loading. The calibration device comprises a sound source module, a fixing module, a control module and a data acquisition module, and the calibration method comprises a sound pressure correction experiment and a calibration experiment. Compared with the prior art, the thin film sensor array calibration device and calibration method based on sound pressure loading have the advantages that a thin film sensor array is calibrated by using sound pressure, so that the uniformity of load borne by measured points on the thin film sensor array is ensured; besides, the sound source module can ensure that the thin film sensor array can be calibrated under any sound pressure and any frequency; meanwhile, the device and the method are suitable for calibration of single measured point and multiple measured points, calibration of low-frequency pressure pulse and high-frequency pressure pulse and calibration of the thin film sensor array in any shape, so that the operation is simple, the calibration is convenient, the generality is strong, and the calibration environment is more suitable for a real working environment.