The invention provides a drive method of four-color display. The method divides multiple ranges of gray scale and determines range of gray scale of mean gray scale of sub-pixel of at least one color to be regulated in the current frame so as to make histogram equalization of sub-pixel of the color of the value of gray scale in the range of gray scale only to enhance change in contrast and gray scale hue of four-color display by histogram equalization, make image clearer and more gorgeous and reinforce effects of image display of four-color display.