Embodiments of the invention provide a novel image sensing unit circuit and a picture element with the same. The novel image sensing unit circuit comprises an image sensing unit circuit and a high-voltage protection module. The image sensing unit circuit is used for amplifying and outputting an electrical signal generated by a high-voltage photoelectric conversion module when the high-voltage photoelectric conversion module is working normally. The high-voltage photoelectric conversion module is connected with a preset high-voltage offset providing end. The high-voltage protection module is connected with the high-voltage photoelectric conversion module and the image sensing unit circuit, and is used for protecting the image sensing unit circuit when the high-voltage photoelectric conversion module is short-circuited. The novel image sensing unit circuit provided by the embodiments of the invention has a high-voltage protection function, so that when the preset high-voltage offset providing end provides a high voltage, (for example, 100V), the image sensing unit circuit only require an ordinary process instead of a special high-voltage process, and the response rate of the high-voltage photoelectric conversion module is ensured. Moreover, the novel image sensing unit circuit has a simple structure and a small area, the circuit performance during normal work is ensured, and large-scale integration is facilitated.