The invention discloses a cefuroxime sodium powder preparation for injection, belonging to the technical field of medicine preparation. The cefuroxime sodium powder preparation for injection is prepared by the following steps: preparation of a sterile formed sodium agent solution, preparation of a sterile cefuroxime acid solution, crystallization and sub-packaging, wherein a two-time grain growing technology is adopted for the crystallization, so that the crystallization quality is improved. With good color and high stability, the product disclosed by the invention greatly improves the quality and safety of cefuroxime sodium, is favorable for improving the national health level, and realizes remarkable economic and social benefits.