The invention discloses a production process for improving bioavailability of ganoderma broken-down wall spore powder. The production process for improving the bioavailability of the ganoderma broken-down wall spore powder is completed through stirring, pelletizing, moisture removing and drying the broken-down wall ganoderma spore powder. The production process for improving the bioavailability of the ganoderma broken-down wall spore powder provided by the invention has the advantages that edible alcohol is used for pelletizing, stirring and extruding are performed in a trough type stirring machine, so that cell walls are better broken; alcohol and water have the characteristic of miscibility and the characteristic of dissolving grease in alcohol, so that nutritional ingredients in the cell walls are transferred to the outside of cells; the nutritional ingredients are collected on the cell walls through processes such as removing the edible alcohol and drying, so that the nutritional ingredients can be quickly and sufficiently absorbed after being taken by a human body, and the bioavailability of the spore powder is effectively improved.