The invention discloses a traditional-Chinese-medicine-compound-targeting lipid nanosphere composite and a preparing method thereof. The composition is prepared from, by weight, 5-15 parts of tanshinone IIA, 10-45 parts of a lipid material, 15-45 parts of an emulsifying agent, 0.00025-0.001 part of modification protein, 35-70 parts of deionized water and 0.00025-0.001 part of a cross-linking agent N-hydroxysuccinimidyl-3-(2-pyridyldithio)propionate. According to the traditional-Chinese-medicine-compound-targeting lipid nanosphere composite and the preparing method, a traditional Chinese medicine compound is wrapped by lipid nanospheres; as the particle size of the lipid nanospheres is small, skin permeation is easy, safety is high, skin stimulation is reduced, forming of melanin of targeted melanocytes can be more easily reduced after protein or polypeptide modification, and the skin whitening effect is achieved.