Systems and methods are provided in example embodiments for mitigating malicious calls. The system can be configured to receive a function call, determine the location of a memory page that initiated the function call, determine if the memory page is associated with a trusted module, and block the function call if the memory page is not associated with the trusted module. In addition, the system can determine the return address for the function call and block the function call if the return address does not belong to the trusted module. Further, the system can determine a parameter for the function call, determine if the parameter is a known parameter used by the process that called the function, and block the function call if the parameter is not the known parameter used by the process that called the function.