Embodiments of methods and apparatuses for resource allocation in a wireless communication system are disclosed. In one embodiment, a method of wireless communication comprises obtaining data to be transmitted over a plurality of sub-channels in a wireless communication environment, determining channel conditions associated with the plurality of sub-channels, scheduling the data to be transmitted according to the channel conditions associated with the plurality of sub-channels to form scheduled data for transmission, and transmitting the scheduled data to one or more receivers via the plurality of sub-channels. The method of determining channel conditions associated with the plurality of sub-channels comprises determining interference observed at each sub-channel in the plurality of sub-channels.