The present invention belongs to the pharmaceutical chemistry field, and particularly relates to a water-soluble triazole compound represented by a formula (I), a pharmaceutically acceptable hydrate and an isomer thereof, wherein the substituents are defined in the specification. According to the present invention, the new group is introduced on the basis of the compound voriconazole widely used in the clinic and having the high-efficiency and broad-spectrum antibacterial effect to form the stable compound having the amphipathic property, such that the solubility and the stability of the compound in the water are improved; and the compound has characteristics of safety, low toxicity and good antibacterial effect, the synthesis of the compound is simple and easy to operate, the purity of the synthesized product is high, and the method is suitable for industrial production. The general I is defined in the specification.