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Invention Grant
CN106479969B 使用HLA-G阳性间充质干细胞治疗系统性红斑狼疮的方法 有权

使用HLA-G阳性间充质干细胞治疗系统性红斑狼疮的方法
Abstract:
本发明涉及使用HLA‑G阳性间充质干细胞治疗系统性红斑狼疮的方法。具体地说，本发明一方面涉及制备用于治疗系统性红斑狼疮的人白细胞抗原‑G阳性的间充质干细胞的方法，该方法包括以下步骤：(1)分离培养HLA‑G+脐带间充质干细胞、(2)HLA‑G+间充质干细胞冻存、(3)HLA‑G+间充质干细胞复苏。本发明方法所制得的间充质干细胞中有90％以上的细胞人白细胞抗原‑G呈阳性。已经发现，本发明HLA‑G+脐带间充质干细胞在治疗系统性红斑狼疮方面具有优异的治疗效果。
Abstract(English):

The invention relates to a method of using HLA-G positive mesenchymal stem cells to treat systemic lupus erythematosus, in particular to, on one hand, a method of preparing human leukocyte antigen-G positive mesenchymal stem cells for treating systemic lupus erythematosus. The system includes following steps: (1), performing isolated culture on HLA-G+umbilical card mesenchymal stem cells; (2), cryopreserving the HLA-G positive mesenchymal stem cells; (3), resuscitating the HLA-G positive mesenchymal stem cells. Higher than 90% of the mesenchymal stem cells prepared by the method is positive to human leukocyte antigen-G. It has been already found that the HLA-G+umbilical card mesenchymal stem cells have excellent effect on treating systemic lupus erythematosus.

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