The invention belongs to the field of drug-containing medical apparatus and instruments, and particularly relates to a drug-containing medical catheter coating and a synthetic method and application thereof. The coating comprises drugs and a drug carrier, drugs are rifampin and minocycline hydrochloride in the mass ratio of 1:1-3, the drug carrier is a polyurethane coating reagent, and the polyurethane coating reagent comprises, by mass, 50-54% of butanone, 25-30.6% of ethyl lactate, 10-12% of tetrahydrofuran, 2.4-2.8% of N-methyl pyrrolidone, 0.8-1% of polyurethane polyvinylpyrrolidone and 3-8% of isocyanate group polyurethane prepolymer. The coating has the biggest advantages that after the coatign is applied to medical catheters, friction coefficient of the catheters is lowered by 97%, bacteriostasis rate reaches 99%, sustained drug release effect reaches one month, and the coating has functions of hydrophilic lubrication, infection resistance, blood congestion resistance, sustained drug release and the like.