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CN106537148A 癌症干细胞的鉴定及其用于诊断和治疗的用途 失效 - 权利终止

癌症干细胞的鉴定及其用于诊断和治疗的用途
Abstract:
公开了一种鉴定人原发性肿瘤中的癌症干细胞标志物的方法。所述方法包括：(a)使所述原发性肿瘤体内传代；并且(b)比较所述原发性肿瘤的第一群传代肿瘤细胞与所述原发性肿瘤的第二群肿瘤细胞中至少一种抗原的水平，其中与所述第二群肿瘤细胞中所述抗原的量相比，所述第一群肿瘤细胞中所述抗原的量增加表明在所述人原发性肿瘤中有癌症干细胞标志物。
Abstract(English):

A method of identifying cancer stem cell markers in a human primary tumor is disclosed. The method comprises: (a) in vivo passaging the primary tumor; and (b) comparing a level of at least one antigen in a first population of passaged tumor cells of the primary tumor with a second population of tumor cells of the primary tumor, wherein an increase in the amount of the antigen in the first population of tumor cells as compared to the amount of the antigen in the second population of tumor cells is indicative of a cancer stem cell marker in the human primary tumor.

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