The invention provides a sustained-release preparation containing tamsulosin hydrochloride and solifenacin succinate. The sustained-release preparation comprises a tamsulosin hydrochloride sustained-release layer and a solifenacin succinate sustained-release layer, wherein the tamsulosin hydrochloride sustained-release layer comprises a glyceryl behenate sustained-release material and a filler; and the solifenacin succinate sustained-release layer is composed of a solifenacin succinate active substance and a diluent and/or a lubricant. The finished product (the sustained-release preparation) provided by the invention is relatively good in stability and is free from hygroscopicity; a burst release phenomenon is avoided in ethanol, a reasonable drug release degree is guaranteed and an action duration is prolonged in accordance with different drug release mechanisms, so that administration times are reduced and patient's compliance is enhanced; and the sustained-release preparation is simple in production process, good in repeatability and high in industrialization degree, and the preparation can achieve enlarged production with the adoption of conventional production equipment.