The invention discloses a multiple leakproof heat exchanger which comprises an infusion tube component and a heat exchange main body; the heat exchange main body comprises a heat exchange outer frame; the heat exchange outer frame is filled with a protective layer; the infusion tube component is at least partly embedded into the protective layer; and a liquid inlet end and a liquid outlet end of the infusion tube component protrude out of the heat exchange main body. Heat exchange equipment provided with the heat exchanger comprises an outer barrel box body; the heat exchanger is integrally arranged in an inner cavity of the outer barrel box body, and is fixedly assembled through a fixing bracket; the outer barrel box body is provided with a heat pipe inlet and a heat pipe outlet that correspond to the liquid inlet end and the liquid outlet end; in addition, the outer barrel box body is also provided with a water inlet and a water outlet. According to the heat exchanger, the infusion tube component is embedded into the protective layer, so that the infusion tube component is effectively prevented from being eroded by the environment and from leaking, and the service life is prolonged. Multiple sets of heat exchangers can be arranged in the heat exchange equipment for improving the heat exchange effect, the heat exchangers can be connected in parallel or in series, and the application scope is wide.