The invention discloses a treatment method of simultaneously removing multiple metal ions in manganiferous waste water. The treatment method comprises the following steps: first adding permanganate into the manganiferous waste water, oxidizing the manganese ions in the manganiferous waste water, and converting Mn<2+> into manganese dioxide floc; then adjusting the pH value of the manganiferous waste water to 7.0-10.0; then conducting stirring at a speed of 200r/min-400r/min to let the manganese dioxide floc mutually collide and enlarge, and conducting stirring at a speed of 10r/min-30r/min to fully adsorb the manganese ions and other coexisting metal ions in the manganiferous waste water; and finally allowing the manganiferous waste water to stand for 30min or above to settle the manganese dioxide floc. The treatment method uses the coagulation of the calcium ions and magnesium ions in the waste water on the manganese dioxide to remove the metal ions in the manganiferous waste water, without adding a coagulant.