The invention discloses a method for improving the anti-oxidation activity of lignin through degradation with laccase. The method comprises: (1) adding an acetic acid solution to a sodium hydroxide solution, and adjusting the pH value to 4.4-6.0 so as to obtain a buffer reagent; (2) adding lignin to prepare a lignin solution or lignin suspension; (3) adding a laccase liquid, carrying out a reaction, and placing the reaction liquid obtained after the reaction in a boiling water bath; and (4) cooling, standing, carrying out suction filtration, washing, drying, and grinding into powder. According to the present invention, the lignin is degraded with the laccase so as to improve the anti-oxidation activity of the lignin, such that the powerful support is provided for the development of the lignin in the natural and renewable antioxidant field, the utilization rate and the economic benefits are increased, and the environmental pollution problem caused by the industrial waste lignin can be solved; and further, the process for the lignin treatment with the laccase has characteristics of low energy consumption, simple operation and no harmful substance generation, and belongs to the energy saving and environmental protection treatment way.