The invention belongs to the technical field of gas expansion refrigeration and relates to an oblique flow re-pressurizing expansion refrigeration device and method. The oblique flow re-pressurizing expansion refrigeration device and method overcome the thermodynamics defect that traditional gas wave refrigerating machine pressure energy is changed into thermal energy, a double-opening pressure exchange gas wave machine serves as an expansion machine to form a refrigerating process with a compressor, one time of compression pressurizing is performed on refrigerating raw material gas in a double-opening oscillation pipe channel by means of the pressure exchange characteristic of a double-opening oscillation pipe, the high-pressure refrigerating gas pressure energy is directly recycled efficiently, and therefore the subsequent power consumption of the compressor is lowered, and the system refrigerating efficiency is improved. The oblique passageway design with the rotating radius changing is adopted for the double-opening oscillation pipe channel of the oblique flow re-pressurizing expansion refrigeration device and method, condensate drops in the oscillation pipe channel are thrown out of a cold end port by means of the rotation centrifugal force of a rotating drum, and the refrigerating efficiency is further improved. The oblique flow re-pressurizing expansion refrigeration device and method can be widely used for low temperature cold gas source supply, natural gas low temperature dehydration, petroleum gas light hydrocarbon recycling and other fields.