The invention relates to a three-dimensional printer multiplex interlocking system which comprises a plurality of multi-nozzle three-dimensional printers, a transportation line, a loading plate and a central control unit; the transportation line is connected among the multi-nozzle three-dimensional printers; the loading plate is arranged in the transportation line, carries out conveying with the transportation line, and is shifted among the multi-nozzle three-dimensional printers; the central control unit is electrically connected with the transportation line and the multi-nozzle three-dimensional printers; the central control unit executes a resolution procedure of a to-be-printed three-dimensional moulding object, sets a printing parameter, establishes a printing schedule, and commands the transportation line and the multi-nozzle three-dimensional printers to transport and printing, so that the loading plate reciprocates among the multi-nozzle three-dimensional printers under the driving of the transportation line, a plurality of jet printing materials are used for carrying out a collaborative three-dimensional printing procedure, and the three-dimensional moulding object is moulded.