The invention relates to a heart valve prosthesis (100, 200, 300, 400, 500) anchored to an interventricular septum (183, 383). The heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313, 518). The valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520), and the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313, 518) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515), one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal end of the valve stitching section (112, 212, 312, 412, 512), and another end of the fixing and supporting section (114, 214, 314, 514) is connected to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and prevent the heart valve prosthesis (100, 200, 300, 400, 500) from axially moving.