The invention discloses a pyrazole sulfamide compound as well as a synthesis method and application thereof. The pyrazole sulfamide compound is a compound with a structure shown as a formula (E) or pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof, disclosed by the invention, can be applied to the aspect of crop weeding, and is especially applied to the aspect of preventing and removing grassy weeds. The compound disclosed by the invention does not have any bad influence on normal growth of rice crops; a safety agent is not needed and the utilization dosage is small; the weeding spectrum is wide and the weeding effect is good; and the pyrazole sulfamide compound is more easily used in agricultural production. (The formula (E) is shown in the description.).