The invention belongs to the technical field of a chemical detection method and particularly relates to a specific method for determining the content of zirconium in a uranium-zirconium alloy by adopting an EDTA (Ethylene Diamine Tetraacetic Acid) titration method. The invention establishes a detection method of the content of the zirconium in the uranium-zirconium alloy by adopting the EDTA titration method. By carrying out experiments including selection of a sample dissolving temperature, an adding amount of hydrofluoric acid, an interference experiment of uranium, titration acidity, a titration temperature and the like and taking 0.2g of a uranium-zirconium alloy sample as the standard, the precision density of the method is better than 1%; and the method is accurate and reliable, and index requirements of a project analysis technology are met.