The present invention discloses a seal friction process on-line intelligent detection diagnosis test system. The system comprises a rubber sealing component, a pipe component, a hollow flexible shaft, an electronic control power component, a horizontal transmission component and an online monitoring component. The seal friction process on-line intelligent detection diagnosis test system is configured to simulate the reciprocating seal of an intelligent device to operate the seal friction fault detection diagnosis test in the true service work condition to obtain the friction of the rubber seal and dirt sediment regulation images in real time so as to obtain the rule according to the test data for improving the seal friction usage efficiency and reliability, selecting appropriate seal structure sizes, elasticity modulus and surface roughness, employing appropriate control parameters and work processes and providing basis for improving seal efficiency and the life of the rubber seal.