The invention relates to a pipe cleaning device and method adopted in the field of pipe cleaning. The cleaning device comprises a cleaning tank, an air compressor and a vacuum pump. An air outlet end opening of the air compressor and a pumping end opening of the vacuum pump are connected with a same pipeline. The pipeline is connected with one or more quick joints used for being connected to one end of a to-be-cleaned pipe in a sealed manner. The air outlet end opening of the air compressor and the pumping end opening of the vacuum pump are each provided with a control valve, wherein the control valves are used for controlling the state of being connected or disconnected with the pipeline. The cleaning method comprises the steps of connecting one end of the to-be-cleaned pipe with the corresponding quick joint, placing the to-be-cleaned pipe into the cleaning tank, and cleaning the outer wall of the to-be-cleaned pipe with a cleaning solution; starting the vacuum pump to pump the to-be-cleaned pipe, so that the to-be-cleaned pipe is filled with the cleaning solution by means of negative pressure; subsequently, switching off the vacuum pump, starting the air compressor, introducing compressed air into the to-be-cleaned pipe, and through expansion of the compressed air, pushing the cleaning solution in the to-be-cleaned pipe to conduct primary cleaning on the inner wall of the to-be-cleaned pipe; and repeating cleaning so that cleaning of the inner wall of the to-be-cleaned pipe can be achieved.