The invention discloses an extended state observer-integrated supercritical thermal power unit turbine-boiler coordinated control method. According to the method, firstly, a plurality of local linear models are established at different working condition points of a power unit through the nonlinear analysis method according to the nonlinear model of a 1000 MW supercritical thermal power unit. Secondly, based on the plurality of local linear models, an extended state observer-integrated multiple model predictive controller (MMPC) is designed. Through the introduction of an extended state observer, the disturbance of the power unit in different channels and the model uncertainty are estimated and compensated. Meanwhile, the disturbance rejection performance of the predictive controller is improved. According to the technical scheme of the invention, based on the above algorithm, the large-scale tracking function for the load of the power unit is realized on the premise that the global stability of the control system is ensured. Meanwhile, the good disturbance rejection performance is realized.