The invention relates to the technical field of ceramic tile processing, especially to a making process for a stain impervious ceramic tile. The process includes pre-trimming, anti-fouling treatment, polishing, edging and chamfering, sorting, packaging and other machining processes. Compared with the prior art, the process eliminates the strickling process, and simplifies the operation procedure. In the anti-fouling treatment process, a special anti-fouling treatment device is employed to perform antifouling paint spray and trowelling simultaneously. In addition, a silica based anti-fouling coating adopted by the invention can closely adhere to the ceramic tile surface to prevent stains from penetrating the ceramic tile, also has high strength, and compared with an anti-fouling membrane formed by waxing, the use time can be longer, and later maintenance is not needed frequently, so that use of the ceramic tile becomes simpler. Therefore, the process provided by the invention can solve the problems of low processing efficiency and troublesome later maintenance of produced ceramic tiles in existing making process.