The invention is suitable for the technical field of finance, provides a method and device for cash replenishing prediction of financial self-service equipment, and aims to solve the problems of low cash utilization rate and high bank operating cost of financial self-service equipment caused by timed and quantitative cash replenishing maintenance in the prior art. The method includes the following steps: obtaining configuration parameters which include the appointed day of cash replenishing prediction, the date range of historical transaction data, collection frequency and the number of samples; according to the configuration parameters, obtaining the historical transaction data corresponding to the appointed day; calculating the cash replenishing amount of the appointed day according to the historical transaction data; and outputting a cash replenishing prediction report according to the cash replenishing amount. The technical scheme of the method realizes prediction of the cash replenishing amount of the appointed day according to the historical transaction data, and can enable management personnel to perform cash replenishing maintenance on the financial self-service equipment as required, thereby improving the cash utilization rate, and reducing the operating cost of a bank.