The invention relates to the field of medicine preparations, and provides a tenofovir disoproxil fumarate, efavirenz and lamivudine triplex compound tablet in tablet and a preparation method thereof. The tablet in tablet comprises a tenofovir disoproxil fumarate coating tablet core, and the tablet core is coated by the efavirenz, the lamivudine and auxiliary materials. The preparation method of the tablet in tablet has the advantages that the problem of degrading and slow dissolving caused by contact with the tenofovir disoproxil fumarate and other two crude drugs is solved; the degrading of the tenofovir disoproxil fumarate caused by contact of the tenofovir disoproxil fumarate with the efavirenz and the lamivudine is effectively avoided, and the good product stability is obtained.